Langerhans cells: not your average dendritic cell
نویسندگان
چکیده
منابع مشابه
Not your average Joe.
For many purposes the most useful transplantable tumour models for human cancer are spontaneous tumours, non-immunogenic in their original host strain, whose cells are also capable of growth in vitro. The necessity for spontaneous origin and demonstrable non-immunogenicity results from the misleading conclusions which may be drawn from experiments using "induced" immunogenic tumours which may b...
متن کاملCorticosteroids prevent generation of CD34+-derived dermal dendritic cells but do not inhibit Langerhans cell development.
Corticosteroids (CS) have been shown to exert strong inhibitory effects on dendritic cell (DC) differentiation and function. Those studies were mostly performed with monocyte-derived DC, which represents only one subpopulation from the wide variety of DC types. In the present study the effects of the CS dexamethasone and prednisolone were investigated on the differentiation of CD34(+) hemopoiet...
متن کاملIncreased blood myeloid dendritic cells and dendritic cell-poietins in Langerhans cell histiocytosis.
Langerhans cell histiocytosis (LCH), previously known as histiocytosis X, is a reactive proliferative disease of unknown pathogenesis. Current therapies are based on nonspecific immunosuppression. Because multiple APCs, including Langerhans cells and macrophages, are involved in the lesion formation, we surmised that LCH is a disease of myeloid blood precursors. We found that lin(-) HLA-DR(+)CD...
متن کاملLangerhans cells and the cells of Langerhans cell histiocytosis do not express DC-SIGN.
vasculitic lesions. Cell-mediated immune (CMI) dysfunction, including defective natural killer cell function has been documented in patients with XLP, and defective CMI may result in altered EBV tissue tropism as we suggest. We agree that many more patients, as well as controls, would need to be studied to definitively answer this issue. The functionality of EBV-specific CTL remains a subject f...
متن کاملDermal dendritic cells, and not Langerhans cells, play an essential role in inducing an immune response.
Langerhans cells (LCs) serve as epidermal sentinels of the adaptive immune system. Conventional wisdom suggests that LCs encounter Ag in the skin and then migrate to the draining lymph nodes, where the Ag is presented to T cells, thus initiating an immune response. Platelet-activating factor (PAF) is a phospholipid mediator with potent biological effects. During inflammation, PAF mediates recru...
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ژورنال
عنوان ژورنال: Trends in Immunology
سال: 2010
ISSN: 1471-4906
DOI: 10.1016/j.it.2010.10.003